SlaveryIssaquena County is notable for its participation in slavery. In 1860, 92.5% of Issaquena County's total population were slaves, the highest concentration of slaves in the United States. The U.S. Census for that year showed that 7,244 slaves were held in Issaquena County, and of 115 slave owners, 39 held 77 or more slaves. Dr. Stephen Duncan of Issaquena County held 858 slaves, second only to Joshua John Ward of South Carolina.
- Washington County (north)
- Sharkey County (northeast)
- Yazoo County (east)
- Warren County (south)
- East Carroll Parish, Louisiana (west)
- Chicot County, Arkansas (northwest)
- Unincorporated places
- Valley Park
EducationThere are no schools located in Issaquena County. Students attend campuses in neighboring Sharkey and Washington counties.
- Public School Districts
- South Delta School District – Based in Rolling Fork; Serves most of Issaquena County including Mayersville.
- Western Line School District – Based in Avon; Serves northwestern portion of Issaquena County.
- Private Schools
- Sharkey-Issaquena Academy – Located in Rolling Fork; Enrollment open to Issaquena County residents.
- Blackwell v. Issaquena County Board of Education, an important 1965 civil rights legal case
- National Register of Historic Places listings in Issaquena County, Mississippi
- Sharkey-Issaquena Academy
- Western Line School District
- South Delta School District
- Valley Park
- Mississippi Delta
- Issaquena County Courthouse Pictures