Sale Creek is an unincorporated community and census-designated place in northern Hamilton County, Tennessee, United States. Its population was 2,845 as of the 2010 census. Sale Creek is home to Sale Creek High School as well as the "haunted" Shipley Hollow Road. Sale Creek was occupied by the 6th Tennessee Infantry US September to December 1863.
The community takes its name from the creek which runs through it, which in turn got its name from the auction at the site of the goods and arms taken from the eleven towns of the militant Cherokee in the region before they were burned during the raid of Evan Shelby's troops in 1779, during the Chickamauga Wars (1776-1794).
It is part of the Chattanooga, TN–GA Metropolitan Statistical Area.